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Basic research shows that drug used to treat multiple sclerosis may have...

(Medical Xpress)—Virginia Commonwealth UniversitySchool of Medicine researchers have uncovered a new mechanism of action of fingolimod, a drug widely used to treat multiple sclerosis: elimination of...

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Potential drug therapy for kidney stones identified in mouse study

(Medical Xpress)—Anyone who has suffered from kidney stones is keenly aware of the lack of drugs to treat the condition, which often causes excruciating pain.

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Genomic survey reveals that abnormal initiation sites for gene expression may...

A*STAR researchers show that changes in histone modifications accelerate a type of stomach tumor known as gastric adenocarcinoma—a cancer that occurs more frequently in Asian populations than Western...

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Are epigenetic drugs a hope to treat cancer resistance and reduce cancer...

(Medical Xpress)—High school biology taught us that we inherit certain traits from our parents that are pre-determined. But what if you could change how these genes play out by taking certain drugs or...

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Embryos receive parent-specific layers of information, study shows

The information that interprets the genetic code in a new embryo differs depending on whether it comes from the father or mother, researchers at San Francisco State University have found.

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Epilepsy treatment could yield cure for McArdle disease

WA scientists may have found a cure for the crippling muscle condition McArdle disease, using a drug already approved for use in humans.

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Farydak approved for multiple myeloma

(HealthDay)—Farydak (panobinostat) has been approved by the U.S. Food and Drug Administration to treat multiple myeloma, a cancer of the blood.

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Recycling histones through transcription

Cells reuse a part of the histones which are used to pack DNA, according to a current study by Karolinska Institutet. The study, which is published in the journal Genome Research, was conducted on...

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Study points to possible treatment for lethal pediatric brain cancer

Using brain tumor samples collected from children in the United States and Europe, an international team of scientists found that the drug panobinostat and similar gene regulating drugs may be...

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Lifelong learning is made possible by recycling of histones, study says

Neurons are a limited commodity; each of us goes through life with essentially the same set we had at birth. But these cells, whose electrical signals drive our thoughts, perceptions, and actions, are...

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Discovery of how environmental memories may be transmitted from a father to...

If you have diabetes, or cancer or even heart problems, maybe you should blame it on your dad's behaviour or environment. Or even your grandfather's. That's because, in recent years, scientists have...

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Newer cancer drug may help protect kidneys from damage caused by older drug

A class of drugs used increasingly to help fight cancer may have the additional benefit of protecting the kidneys when packaged with the powerful chemotherapy agent cisplatin.

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SCCM: circulating histones for most with thrombocytopenia

(HealthDay)—Most patients with thrombocytopenia have circulating histones, according to a research letter published online Feb. 22 in the Journal of the American Medical Association to coincide with...

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New formulation of FDA-approved drug may help treat Niemann-Pick Type C disease

Niemann-Pick Type C (NPC) disease is a rare, fatal neurodegenerative disease for which there is currently no cure. NPC primarily strikes children before and during adolescence and affects one in every...

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Gene regulatory mutation linked to rare childhood cancer

A single defect in a gene that codes for a histone—a "spool" that wraps idle DNA—is linked to pediatric cancers in a study published today in the journal Science.

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Diabetes linked to changes in gene behaviour driven by environment

Why gestational diabetes leads to type 2 diabetes has baffled medical science for decades, but new research led by Deakin University has shown the answer could be in our genes' ability to change their...

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Enzyme shows therapeutic potential for breast cancer and other diseases

Aspirin's reign as "the wonder drug" may have a serious challenger if new research by a team of scientists from the United States and Brazil pans out. That's because they have identified an enzyme,...

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Protein ZMYND8 tied to suppression of prostate cancer tumor metastasis

Although it reads like European license plate number, a protein known as ZMYND8 has demonstrated its ability to block metastasis-linked genes in prostate cancer, according to a study at The University...

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New discovery in understanding chemotherapy resistance could prevent cancer...

Scientists have made an important breakthrough in understanding why some cancer cells become resistant to chemotherapy.

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Enzyme's 'editing' preferences have implications for infertility and cancer

To "turn off" particular regions of genes or protect them from damage, DNA strands can wrap around small proteins, called histones, keeping out all but the most specialized molecular machinery. Now,...

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New finding reveals battle behind gene expression

The complex process regulating gene expression is often compared to following a recipe. Miss a genetic ingredient, or add it in the wrong order, and you could have a disaster on your hands.

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New pharmacon allows testicular tumors to shrink

Testicular cancer is the most common malignant tumor disease in men between 20 and 40 years of age. It can usually be treated well. In some cases, however, the cancer hardly responds or does not...

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Study ties protein 'reader' ENL to common leukemia

Anyone who uses an employee badge to enter a building may understand how a protein called ENL opens new possibilities for treating acute myeloid leukemia (AML), a fast-growing cancer of bone marrow and...

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Epigenetic program leading to vessel differentiation

Clarification of how human blood vessels are constructed is desperately needed to advance regenerative medicine. A collaborative research group from Kumamoto University, Kyoto University, and the...

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New target found to attack an incurable brain tumor in children

A study published in Molecular Cancer Research reveals that a tumor suppressor gene p16 is turned off by a histone mutation (H3.3K27M), which is found in up to 70 percent of childhood brain tumors...

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Mutant yeast reveals details of the aberrant genomic machinery of children's...

St. Jude Children's Research Hospital biologists have used engineered yeast cells to discover how a mutation that is frequently found in pediatric brain tumor high-grade glioma triggers a cascade of...

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Study finds N-alpha-acetyltransferase D (NatD) promotes lung cancer progression

Researchers at Nanjing University and their collaborators have found that NatD, which mediates N-alpha-terminal acetylation (Nt-acetylation) of histone H4, promotes lung cancer progression by...

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Possible approach discovered for treating multiple sclerosis

Around 2.5 million people are affected by the autoimmune disease multiple sclerosis (MS), the most common central nervous system disease among young adults. There are around 12,500 MS sufferers in...

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DIPG tumor patterns offer new insight on survival

The prognosis for all children diagnosed with an aggressive brain tumor known as diffuse intrinsic pontine glioma (DIPG) and similar tumors has been mostly the same: dismal.

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Discovery may advance neural stem cell treatments for brain disorders

New research from Sanford Burnham Prebys Medical Discovery Institute (SBP) is among the first to describe how an mRNA modification impacts the life of neural stem cells (NSCs). The study, published in...

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